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KMID : 0648420100150020093
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Journal of Korean Society of Pediatric Endocrinology
2010 Volume.15 No. 2 p.93 ~ p.99
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The Clinical Characteristics of Type 2 Diabetes Mellitus with and without β-cell Autoantibody in Children and Adolescents
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Ji Min-Chul
Chae Hyun-Wook
Kim Ho-Seong
Kim Duk-Hee
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Abstract
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Purpose : The aim of this study is to investigate the differences in clinical characteristics and disease process between autoantibody-positive and -negative patients with type 2 diabetes mellitus (DM).
Methods : We investigated 162 patients diagnosed as DM between January 2000 and July 2009. 120 were classified as type 1 and 42 as type 2 DM. The clinical and laboratory data were obtained from medical records, retrospectively.
Results : The age at diagnosis, average BMI and serum C-peptide levels were significantly higher in type 2 DM patients than in type 1 DM patients. Type 2 DM patients had a significantly higher family history of diabetes and less frequent ketonuria. There were no significant differences between autoantibody-positive and -negative type 2 DM patients in age at diagnosis, BMI, C-peptide levels, HbA1c levels or family history. During the follow-up period, C-peptide levels were lower in the autoantibody-positive group than in the autoantibody-negative group, while. HbA1c levels were higher in the autoantibody-positive group. However, these differences were not statistically significant.
Conclusion : In autoantibody-positive type 2 DM patients, progressive loss of β-cell function leads to reduced insulin secretion and poor glycemic control as the disease progresses, and some may be reclassified as slowly progressive type 1 DM. Ccntinued and careful follow-up is therefore needed.
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KEYWORD
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Diabetes mellitus, type 2, Autoantibodies Child, Adolescent
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